Methadone Treatment & Alternatives

Methadone and Suboxone are both opioid medications used in Medication-Assisted Treatment (MAT) for opioid addiction. While they share similarities, there are key differences to consider when choosing the most appropriate treatment option.  

Methadone:

• Full Opioid Agonist: Methadone activates opioid receptors in the brain, producing a mild opioid effect.  
• Higher Dependence Potential: Can lead to stronger physical dependence and more challenging withdrawal.  
• Dispensed Only in Specialized Clinics: Due to its potential for abuse and diversion, methadone can only be dispensed in specialized clinics under strict regulations.  
• Daily Dosing: Typically requires daily visits to a clinic for observed dosing, especially in the initial stages of treatment.

Suboxone:

• Partial Opioid Agonist: Suboxone contains buprenorphine, a partial agonist that activates opioid receptors with a weaker effect than methadone. It also contains naloxone, an opioid antagonist that blocks the effects of other opioids and helps deter misuse.  
• Lower Dependence Potential: Generally considered to have a lower potential for dependence and less severe withdrawal symptoms compared to methadone.  
• Can be Prescribed by Certified Physicians: Suboxone can be prescribed by physicians who have completed specialized training and certification.  
• More Flexible Dosing: Can be taken at home as a sublingual film or tablet, allowing for greater flexibility and less frequent visits to a healthcare provider.